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The term drug overdose (or simply overdose or OD ) describes the ingestion or application of a drug or other substance in quantities greater than are recommended  or generally practiced.  An overdose may result in a toxic state or death . 
An overdose is when you take more than the normal or recommended amount of something, usually a drug. An overdose may result in serious, harmful symptoms or death.
Drug overdoses can be accidental or intentional. They occur when a person takes more than the medically recommended dose. However, some people may be more sensitive to certain medications , so the low (more dangerous) end of a drug may be toxic for them; a dose that is still within the range of acceptable medical use may be too much for their bodies to handle.